Circulating CC16 and Asthma: a Population-Based, Multi-Cohort Study from Early Childhood Through Adult Life
Rationale: Club cell secretory protein (CC16) is an antiinflammatory protein highly expressed in the airways. CC16 deficiency has been associated with lung function deficits, but its role in asthma has not been established conclusively. Objectives: To determine 1) the longitudinal association of circulating CC16 with the presence of active asthma from early childhood through adult life and 2) whether […]
CC16 Binding to α4β1 Integrin (VLA-4) Protects Against Mycoplasma pneumoniae Infection
Rationale CC16 (club cell secretory protein) is a pneumoprotein produced predominantly by pulmonary club cells. Circulating CC16 is associated with protection from the inception and progression of the two most common obstructive lung diseases (asthma and chronic obstructive pulmonary disease). Objectives Although exact mechanisms remain elusive, studies consistently suggest a causal role of CC16 in mediating antiinflammatory […]
CC16 Deficiency in the Context of Early Life Mycoplasma pneumoniae Infection Results in Augmented Airway Responses in Adult Mice
Studies have shown that club cell secretory protein (CC16) plays important protective roles in the lungs, yet its complete biological functions are unclear. We devised a translational mouse model in order to investigate the impact of early life infections, in the context of CC16 deficiency, on lung function in adult mice. CC16 sufficient (WT) and […]
Club Cell Secretory Protein Deficiency Leads to Altered Lung Function
Rationale: CC16 (club cell secretory protein-16), a member of the secretoglobin family, is one of the most abundant proteins in normal airway secretions and has been described as a serum biomarker for obstructive lung diseases. Objectives: To determine whether low CC16 is a marker for airway pathology or is implicated in the pathophysiology of progressive airway damage […]
Trajectories and Early Determinants of Circulating CC16 from Birth to Age 32 Years
The club cell secretory protein CC16 is a pneumoprotein present in circulation but mainly produced by club cells and other nonciliated airway epithelial cells (1–3). Its biological functions have not been conclusively elucidated, but findings from in vitro studies (4) and mouse models (5) support antiinflammatory and antitoxicant properties of CC16 in the lung. In line with […]
Effects of Retinoids on Augmentation of Club Cell Secretory Protein
Club cell secretory protein (CC16; encoding gene, SCGB1A1) is a homodimeric pneumoprotein that is produced mainly by club cells and other nonciliated epithelial cells in both proximal and distal airways (1). Higher airway expression and circulating levels of CC16 have been associated cross-sectionally with better lung function and lower prevalence and severity of chronic obstructive pulmonary […]
The Relation of Circulating CC16 to Lung Function Growth, Decline, and Development of COPD Across the Lifespan
Background Low serum levels of the anti-inflammatory club cell secretory protein (CC16) have been associated with an accelerated FEV1 decline in COPD. Whether low circulating CC16 precedes lung function deficits and incidence of COPD in the general population is unknown. Methods We used longitudinal data from adults who were COPD-free at baseline from the population-based […]