CC16 Binding to α4β1 Integrin (VLA-4) Protects Against Mycoplasma pneumoniae Infection
Rationale CC16 (club cell secretory protein) is a pneumoprotein produced predominantly by pulmonary club cells. Circulating CC16 is associated with protection from the inception and progression of the two most common obstructive lung diseases (asthma and chronic obstructive pulmonary disease). Objectives Although exact mechanisms remain elusive, studies consistently suggest a causal role of CC16 in mediating antiinflammatory […]
Club Cell Secretory Protein Deficiency Leads to Altered Lung Function
Rationale: CC16 (club cell secretory protein-16), a member of the secretoglobin family, is one of the most abundant proteins in normal airway secretions and has been described as a serum biomarker for obstructive lung diseases. Objectives: To determine whether low CC16 is a marker for airway pathology or is implicated in the pathophysiology of progressive airway damage […]
Club Cell Secretory Protein in Serum and Bronchoalveolar Lavage of Patients with Asthma
Club cell secretory protein (CC16) is a homodimeric pneumoprotein that is mainly produced by nonciliated bronchial epithelial cells1,2 and is found both in the airways and in the circulation. The biological functions of CC16 have not been conclusively determined, but in vitro, ex vivo, and animal studies indicate anti-inflammatory, immunomodulatory, and antitoxicant properties of this molecule in the lungs.1,2 Clinical […]