Circulating CC16 and Asthma: a Population-Based, Multi-Cohort Study from Early Childhood Through Adult Life
Rationale: Club cell secretory protein (CC16) is an antiinflammatory protein highly expressed in the airways. CC16 deficiency has been associated with lung function deficits, but its role in asthma has not been established conclusively. Objectives: To determine 1) the longitudinal association of circulating CC16 with the presence of active asthma from early childhood through adult life and 2) whether […]
Trajectories and Early Determinants of Circulating CC16 from Birth to Age 32 Years
The club cell secretory protein CC16 is a pneumoprotein present in circulation but mainly produced by club cells and other nonciliated airway epithelial cells (1–3). Its biological functions have not been conclusively elucidated, but findings from in vitro studies (4) and mouse models (5) support antiinflammatory and antitoxicant properties of CC16 in the lung. In line with […]