Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity
In brief Plasma proteomics may capture key insights into disease mechanisms and reveal informative biomarkers. Donoghue et al. apply a causal inference framework to genetic and plasma proteomic data from the UK Biobank and demonstrate that genetically predicted protein levels are effective instruments for identifying putatively causal factors underlying both disease risk and heterogeneity. […]