Club Cell Secretory Protein in Serum and Bronchoalveolar Lavage of Patients with Asthma
Club cell secretory protein (CC16) is a homodimeric pneumoprotein that is mainly produced by nonciliated bronchial epithelial cells1,2 and is found both in the airways and in the circulation. The biological functions of CC16 have not been conclusively determined, but in vitro, ex vivo, and animal studies indicate anti-inflammatory, immunomodulatory, and antitoxicant properties of this molecule in the lungs.1,2 Clinical […]
The Relation of Circulating CC16 to Lung Function Growth, Decline, and Development of COPD Across the Lifespan
Background Low serum levels of the anti-inflammatory club cell secretory protein (CC16) have been associated with an accelerated FEV1 decline in COPD. Whether low circulating CC16 precedes lung function deficits and incidence of COPD in the general population is unknown. Methods We used longitudinal data from adults who were COPD-free at baseline from the population-based […]